解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
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神经系统科学
护理
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产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
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运动科学
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毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Many flavonoids and isoflavonoids have anti-diabetic effects in animal models. However, the mechanisms that are involved are generally unclear. Since 11β-hydroxysteroid dehydrogenases (HSD11Bs) play important roles in diabetes, we hypothesize that flavonoids and isoflavonoids may affect diabetes by targeting two isofo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.01.013
更新日期:2018-04-01 00:00:00
abstract::A series of amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid (1) with the polyamine spermine and three other diamines, 1,2-diaminoethane, piperazine and cadaverine, were synthesized and their antimicrobial activity and cytotoxicity were investigated. Among the target compounds, several one...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.10.011
更新日期:2017-12-01 00:00:00
abstract::Novel deoxycholic acid (DCA) derivatives were stereoselectively synthesised with -OH and -CH2SR moieties at the C-3 position, where R was a substituted aryl [2-aminophenyl (8) or 4-chlorophenyl (9)] or hetaryl [1-methylimidazolyl (5), 1,2,4-triazolyl (6), 5-amino-1,3,4-thiadiazolyl (7), pyridinyl (10) or pyrimidinyl (...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.08.016
更新日期:2017-11-01 00:00:00
abstract::Aspergillus niger, one of fungal species most frequently used for experimental and industrial-scale biotransformations of various organic compounds, is generally known to transform steroids at 16β position. In this work, application of the strain A. niger KCH910 to bioconversion of dehydroepiandrosterone (DHEA), andro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.08.009
更新日期:2017-10-01 00:00:00
abstract::Biotransformation of an orally active contraceptive drug, drospirenone (1), by Cunninghamella elegans ATCC 36114 yielded four new metabolites, 6β,7β,15β,16β-dimethylene-3-oxo-14α-hydroxy-17α-pregn-4-ene-21,17-carbolactone (2), 6β,7β,15β,16β-dimethylene-3,11-dioxo-17α-pregn-4-ene-21,17-carbolactone (3), 6β,7β,15β,16β-d...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.07.010
更新日期:2017-10-01 00:00:00
abstract::Novel androstanopyrazoles have been efficiently synthesized from steroidal β-ketoaldehydes with different arylhydrazine hydrochlorides both under acidic and basic conditions. Knorr-type transformations of 16-hydroxymethylene-dehydroepiandrosterone containing its 1,3-dicarbonyl moiety on ring D, proved to be regioselec...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.08.003
更新日期:2017-10-01 00:00:00
abstract::Brassinosteroids (BRs) control several important agronomic traits, such as strengthening resistance to diverse adversity, improving the quality, and increasing crop yield. Their chemical structures and varieties, specific methods for the evaluation of bioactivities, structure-activity relationships, potential novel co...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2017.05.005
更新日期:2017-08-01 00:00:00
abstract::Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium(II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. Coordination via the thionic sulfur and the azomethine nitrogen atom of the thiosemicarbazone to the Ru(II) metal. Steroidal thiosemicarbazone derivatives were obtained...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.05.001
更新日期:2017-08-01 00:00:00
abstract::In the present study, synthesis and antineoplastic activity of phenylacetic acid and benzoic acid nitrogen mustard conjugates of various steroidal oximes are reported for the first time. The conjugation was achieved through a more stable oxime-ester linkage and the resulting newly synthesized conjugates were evaluated...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.04.005
更新日期:2017-07-01 00:00:00
abstract::Allopregnanolone (3α-THP) is one of the main reduced progesterone (P4) metabolites that is recognized as a neuroprotective and myelinating agent. 3α-THP also induces proliferation of different neural cells. It has been shown that P4 favors the progression of glioblastomas (GBM), the most common and aggressive primary ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.01.004
更新日期:2017-03-01 00:00:00
abstract::The reduction of 17-oxosteroids to 17β-hydroxysteroids is one of the important transformations for the preparation of many steroidal drugs and intermediates. The strain Zygowilliopsis sp. WY7905 was found to catalyze the reduction of C-17 carbonyl group of androst-4-ene-3,17-dione (AD) to give testosterone (TS) as the...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.11.002
更新日期:2017-02-01 00:00:00
abstract::From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related steroids (2-3) have been isolated and characterized along with a known cycloartane derivative (4). The chemical structure of the obtusifoliol-related compounds, obtained by 1D and 2D NMR, and MS measurements, have been determined as: 3...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.07.008
更新日期:2016-11-01 00:00:00
abstract::A phytochemical study of Physalis pubescens L. afforded twelve compounds, including six new withanolides (1, 4, and 6i-9), four new withanolide glucosides (2, 3, 5, and 6), and two known withanolides (10 and 11). Their structures were established via extensive spectroscopic analysis. The absolute configuration of 3 wa...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.09.002
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Abnormal secretion of thyroid hormones, growth hormone, cortisol and androgens influences body composition. We hypothesised that higher cortisol excretion, in combination with higher androgen and IGF-I concentrations, had a synergistic, favourable effect on body mass and bone. DESIGN, PATIENTS AND METHODS:Th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.09.006
更新日期:2016-11-01 00:00:00
abstract::In this study, effects of estradiol, progesterone and genistein on uterine aquaporin (AQP)-1, 2, 5 and 7 expression were investigated in sex-steroid deficient state which could help to elucidate the mechanisms underlying uterine fluid volume changes that were reported under these hormone and hormone-like compound infl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.08.007
更新日期:2016-11-01 00:00:00
abstract::To identify new pathways of estrogen action and novel estrogen receptor α (ERα) biomodulators, we performed high throughput screening and used follow on assays and bioinformatics to identify small molecule ERα inhibitors with a novel mode of action. These studies led to identification of rapid extranuclear activation ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2016.03.014
更新日期:2016-10-01 00:00:00
abstract::Bioconversion of the aromatase inhibitor formestane (4-hydroxyandrost-4-ene-3,17-dione) (1) by the fungus Rhizopus oryzae ATCC 11145 resulted in a new minor metabolite 3,5α-dihydroxyandrost-2-ene-4,17-dione (2) and the known 4β,5α-dihydroxyandrostane-4,17-dione (3) as the major product. The structural elucidation and ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.07.003
更新日期:2016-09-01 00:00:00
abstract::The crystal structure of a Li(+) salt of a glucosyl derivative of lithocholic acid (lithium 3α-(α-d-glucopyranosyl)-5β-cholan-24-oate) has been solved. The crystal belongs to the orthorhombic system, P212121 spatial group, and includes acetone and water in the structure with a 1:1:2 stoichiometry. Monolayers, having a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.07.001
更新日期:2016-09-01 00:00:00
abstract::Acrolein, an α, β-unsaturated aldehyde, exists in a wide range of sources. Acrolein can be not only generated from all types of smoke but also produced endogenously from the metabolism by lipid peroxidation. The cellular influence of acrolein is due to its electrophilic character via binding to and depleting cellular ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.03.009
更新日期:2016-07-01 00:00:00
abstract::Glucocorticoids (GCs) and progesterone have been employed as immunosuppressive agents during pregnancy for many years. Intracellular acidification by GCs is due to a rapid non-genomic inhibition of membrane Na(+)/H(+)-exchange 1 (NHE1) activity and is followed by immunosuppression of PHA-stimulated proliferation. NHE1...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.01.004
更新日期:2016-07-01 00:00:00
abstract::We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.04.001
更新日期:2016-06-01 00:00:00
abstract::Fingernail clipping is expected to be a specimen for steroid testing, because it has several advantages over blood; i.e., noninvasive collection, ease of storage, portability and handling, and possibility for an assessment of the steroid status over a relatively long and retrospective time window. In this study, we ex...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.02.013
更新日期:2016-05-01 00:00:00
abstract::Two dimeric steroidal terephthalates derived from epimeric 4,5-seco-cholest-3-yn-5-ols were prepared starting from cholesterol in a five-step synthetic sequence. X-ray crystallography shows that the obtained compounds display novel supramolecular networks in the solid state in which the facial hydrophobicity of the st...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.03.001
更新日期:2016-05-01 00:00:00
abstract::Catalytic cycloalumination of (3β,5α)-3-vinylcholestane and (3α,5α)-3-allylcholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give previously unknown aluminacyclopentanes in ∼90% yield; these products were converted in situ to carbo- and heterocyclic (5α)-cholestane derivatives. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.01.015
更新日期:2016-04-01 00:00:00
abstract::Steroids possessing an ethynyl group at position 17α (tertiary alcohols) are well known to be more stable than their non-ethynyl analogs (secondary alcohols). To facilitate the development of new drugs with better metabolic stability, we developed a new diethylsilyl acetylenic linker allowing us to rapidly synthesize ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.12.019
更新日期:2016-03-01 00:00:00
abstract::The giant freshwater prawn, Macrobrachium rosenbergii, is important to many Asian countries due to its high economic value as an aquaculture product. With demand increasing, there is requirement for a better understanding of the biosynthetic components that regulate its growth and reproduction, including steroids, in ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.01.006
更新日期:2016-03-01 00:00:00
abstract::This study was designed to describe the time-course changes of catabolic proteins following muscle atrophy induced by 10 days of dexamethasone (DEX). Rats underwent DEX treatment for 1, 3, 5, 7 and 10 days. Body weight (BW) and lean mass were obtained using a dual energy X-ray absorptiometry (DEXA) scan. Muscle ringer...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.12.016
更新日期:2016-03-01 00:00:00
abstract::Steroids have been shown to have multiple effects on the nervous system including neuroprotective activities, and they have the potential to be used for the treatment of neurodegenerative diseases. In this current study, we tested the hypothesis that the marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol (Tetro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.11.005
更新日期:2016-01-01 00:00:00
abstract::Biotransformation of danazol (1) (17β-hydroxy-17α-pregna-2,4-dien-20-yno-[2,3-d]-isoxazole) with Cunninghamella blakesleeana yielded three new metabolites 2-4 and a known metabolite 5. These metabolites were identified as 14β,17β-dihydroxy-2-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2), 1α,17β-dihydroxy-17α-pregna-2...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.11.010
更新日期:2016-01-01 00:00:00
abstract::Structural modifications of natural products with complex structures like steroids require great synthetic effort. A review of literature is presented on the chemistry of the steroidal hormone 17α-methyltestosterone that is approved by Food and Drug Administration (FDA) in the United States as an androgen for estrogen...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2015.11.004
更新日期:2016-01-01 00:00:00
abstract::Gypensapogenin H (GH) is a novel dammarane-type triterpenes obtained from hydrolyzate of total saponins from Gynostemma pentaphyllum and its anti-tumor activity has been studied in previous work. In this study, we report the effects of this compound on human prostate cancer cells (DU145 and 22RV-1). It significantly i...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.10.014
更新日期:2015-12-01 00:00:00
abstract::To simultaneously measure some targeted endocrine disruptors and several forms of sex hormones in rat serum, an accurate analytical procedure was developed. First, a comparison between a polymeric-based solid-phase extraction (SPE) and a micro-extraction by packed sorbent was performed to choose the optimal method to ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.10.011
更新日期:2015-12-01 00:00:00
abstract::A new spirostane steroidal saponin, govanoside A (1) along with three known compounds borassoside E (2) pennogenin (3) and diosgenin (4) were isolated from rhizomes of Trillium govanianum. Their structures were elucidated through 1D, 2D-NMR spectroscopic data analysis and acid hydrolysis. Compound (2) in genus Trilliu...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.10.013
更新日期:2015-12-01 00:00:00
abstract::Brassinosteroid (BR) phytohormones play indispensable roles in plant growth and development. Brassinolide (BL) and 24-epibrassinolide (24-epiBL) are the most active ones among the BRs reported thus far. Unfortunately, the extremely low natural content and intricate synthesis process limit their popularization in agric...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.09.002
更新日期:2015-12-01 00:00:00
abstract::Steroid hormones are involved in the regulation of a variety of processes like embryonic development, sex differentiation, metabolism, immune responses, circadian rhythms, stress response, and reproduction in vertebrates. Teleost fishes and humans show a remarkable conservation in many developmental and physiological ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2015.06.011
更新日期:2015-11-01 00:00:00
abstract::Three BS-BODIPY (brassinosteroids-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) conjugates were synthesized and their fluorescent and immunological properties were investigated. Two of the conjugates, having present all the functional groups characteristic of BS, were shown to be potentially useful as biological probes ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.07.002
更新日期:2015-10-01 00:00:00
abstract::The main purpose of this review article is threefold (a) to try to address the question "why are two adrenal glucocorticoids, cortisol and corticosterone, secreted by humans and other mammalian species?", (b) to outline a hypothesis that under certain physiological conditions, corticosterone has additional biochemical...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2015.06.017
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Serum progesterone (P) rises after ovulation in the luteinisation process. OBJECTIVE:To identify an accurate progesterone threshold to confirm ovulation in the assessment of a woman's fertility. METHODS:In a secondary analysis of an observational European multicentre study, this study included 107 women ov...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.06.013
更新日期:2015-09-01 00:00:00
abstract::Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Δ(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetyl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.06.005
更新日期:2015-09-01 00:00:00
abstract::Inhibition of concise enzymes in ergosterol biosynthesis is one of the most prominent strategies for antifungal chemotherapy. Nevertheless, the enzymes sterol C5-desaturase and sterol C22-desaturase, which introduce double bonds into the sterol core and side chain, have not been fully investigated yet for their potent...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.05.004
更新日期:2015-09-01 00:00:00